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Antimicrobial therapy in acute pancreatitis
| Classification | Duration of antimicrobial therapy | Recommendation |
|---|---|---|
| Mild | No antibiotics (grade 2A) | No antibiotics (grade 2A) |
| Severe | Up to 14 d (grade 3B) |
-Empiric therapy: CAR (IPM or MEM) (grade 3B) -CAR sparing regimen: TZP or FQ (if proven antibiotic susceptibility of the recovered organisms) (grade 3B) |
| Infected pancreatic necrosis |
KEY: CAR carbapenems, d days, FQ fluoroquinolone, IPM imipenem, MEM meropenem, TZP piperacillin/tazobactam
