Table 6.
Dosing of antimicrobials used in the management of intra-abdominal infections in adults with normal renal function
| Antimicrobials | Dose |
|---|---|
| β-lactam/β-lactamase inhibitor combination | |
| AMC | 2.2 g IV every 6 h; 2 h infusion timea |
| TZP | 4.5 g IV every 6 h; 3 h infusion time |
| C/T | 1.5 g IV every 8 h |
| CZA | 2.5 g IV every 8 h |
| Carbapenems | |
| ETP | 1 g IV every 24 h, consider 2 h infusion time |
| IPM | 1 g IV every 8 h |
| MEM | 1 g IV every 8 h; consider 2 g IV loading dose; 4 h hour infusion time |
| Cephalosporins | |
| CXM | 1.5 g IV every 8 h |
| CRO | 2 g IV every 12–24 h |
| CTX | 1–2 g IV every 6–8 h |
| ZOX | 1–2 g IV every 8–12 h |
| FEP | 2 g IV every 8 h |
| CAZ | 2 g IV every 8 h |
| Glycylcyclines | |
| TGC | 100 mg IV loading dose, then 50 mg IV every 12 h |
| Polymyxin | |
| Colistimethate sodium | 9 million IU IV loading dose, then 4.5 million IU IV q12 h |
| Aminoglycosides | |
| GEN | 5–7 mg/kg IV every 24 h |
| AMK | 15–20 mg/kg IV every 24 h |
| Fluoroquinolones | |
| CIP | 400 mg IV every 8–12 h or 500 mg PO every 8–12 h |
| LVX | 750 mg every 24 h (IV or PO) |
| MOX | 400 mg every 24 h (IV or PO) |
| Metronidazole | 500 mg every 8-12 h or 1500 mg every 24 h (IV or PO) |
| Glycopeptides | |
| VAN | 25–30 mg/kg IV loading dose, then 15–20 mg/kg IV every 8–12 h; target trough 15–20 mg/dL |
| TEC | 12 mg/kg IV every 12 h for 3 doses (loading dose), then 6–12 mg/kg IV every 24 h |
| Oxazolidinone | |
| LZD | 600 mg every 12 h (IV or PO) |
| Azoles | |
| FLC | 800 mg IV loading dose then 400 mg IV every 24 h; 2 h infusion time |
| Echinocandins | |
| CAS | 70 mg IV loading dose first day, then 50 mg IV daily |
| MFG | 100 mg daily |
| AFG | 200 mg loading dose first day, then 100 IV mg daily |
KEY: AFG anidulafungin, AMC amoxicillin/clavulanic acid, AMK amikacin, CAS caspofungin, CAZ ceftazidime, CIP ciprofloxacin, CRO ceftriaxone, CTX cefotaxime, CXM cefuroxime, CZA ceftazidime/avibactam, C/T ceftolozane/tazobactam, ETP ertapenem, FEP cefepime, FLC fluconazole, GEN gentamicin, IPM imipenem, IU international units, IV intravenous, LVX levofloxacin, LZD linezolid, MEM meropenem, MFG micafungin, MOX moxifloxacin, PO per os, TEC teicoplanin, TGC tigecycline, TZP piperacillin/tazobactam, VAN vancomycin, ZOX ceftizoxime