Table 4.

Single variant test and cumulative allele odds ratio of RNF213 rare variants

Variant	Ref	Alt	Case_Ref	Case_Alt	Control_Ref	Control_Alt	OR	95%CI	p value*
Chr17:78247076–78,247,076	C	–	499	1	2430	0	–	–	0.171
Chr17:78298891	T	C	499	1	2430	0	–	–	0.171
Chr17:78307986	G	T	499	1	2430	0	–	–	0.171
Chr17:78311532	C	T	498	2	2419	11	0.88	(0.20–4.00)	1.000
Chr17:78311620	A	G	499	1	2430	0	–	–	0.171
Chr17:78313764	C	T	494	6	2414	16	1.83	(0.71–4.71)	0.248
Chr17:78318465	C	G	496	4	2403	27	0.72	(0.25–2.06)	0.383
Chr17:78319385	T	G	494	6	2408	22	1.33	(0.54–3.30)	0.716
Chr17:78326772	C	T	499	1	2429	1	4.87	(0.30–77.95)	0.312
Chr17:78350088	T	C	489	11	2392	38	1.42	(0.72–2.79)	0.312
Chr17:78353469	T	C	499	1	2430	0	–	–	0.171
Chr17:78354738	G	A	499	1	2430	0	–	–	0.171
Chr17:78355494	C	G	499	1	2429	1	4.87	(0.30–77.95)	0.312
Chr17:78356830	G	T	499	1	2430	0	–	–	0.171
Chr17:78357541	A	T	499	1	2430	0	–	–	0.171
Chr17:78360656	C	T	499	1	2429	1	4.87	(0.30–77.95)	0.312
Chr17:78362497	C	T	499	1	2430	0	–	–	0.171
Chr17:78363181	C	T	499	1	2430	0	–	–	0.171
Total counts			8958	42	43,623	117	1.74	(1.23–2.49)	0.002

^*P values were calculated using a two-sided Fisher’s exact test

Ref Reference allele(s), Alt Alternate allele(s)

Case = 250 ICASO patients, Control = 1KG Chinese Han population and GeneSky Database(including 1007 healthy individuals)