Table 2.
The gene ontology analysis of potential key genes in melanomas
| ID | Term | Count | p-value | Genes |
|---|---|---|---|---|
| GO:0016788 | hydrolase activity, acting on ester bonds | 2 | 0.00465 | CYR61, RNASE4 |
| GO:0090304 | nucleic acid metabolic process | 3 | 0.02260 | CYR61, DUSP1, RNASE4 |
| GO:0008219 | cell death | 2 | 0.03509 | CYR61, DUSP1 |
| GO:0071495 | cellular response to endogenous stimulus | 2 | 0.01713 | CYR61, DUSP1 |
| GO:0071310 | cellular response to organic substance | 2 | 0.04895 | CYR61, DUSP1 |
| GO:0009790 | embryo development | 2 | 0.008327 | CYR61, DUSP1 |
| GO:0048598 | embryonic morphogenesis | 2 | 0.00303 | CYR61, DUSP1 |
| GO:0019838 | growth factor binding | 2 | 0.00014 | CYR61, DUSP1 |
| GO:0006915 | apoptotic process | 2 | 0.03095 | CYR61, DUSP1 |
| GO:0043066 | negative regulation of apoptotic process | 2 | 0.00673 | CYR61, DUSP1 |
| GO:0060548 | negative regulation of cell death | 2 | 0.007915 | CYR61, DUSP1 |
| GO:0043069 | negative regulation of programmed cell death | 2 | 0.00688 | CYR61, DUSP1 |
| GO:0048646 | anatomical structure formation involved in morphogenesis | 2 | 0.01169 | CYR61, DUSP1 |
| GO:0016310 | phosphorylation | 2 | 0.04169 | CYR61, DUSP1 |
| GO:0043065 | positive regulation of apoptotic process | 2 | 0.00311 | CYR61, DUSP1 |
| GO:0010942 | positive regulation of cell death | 2 | 0.00354 | CYR61, DUSP1 |
| GO:0043068 | positive regulation of programmed cell death | 2 | 0.00316 | CYR61, DUSP1 |
| GO:0012501 | programmed cell death | 2 | 0.03166 | CYR61, DUSP1 |
| GO:0006468 | protein phosphorylation | 2 | 0.02993 | CYR61, DUSP1 |
| GO:0006508 | proteolysis | 2 | 0.02311 | CYR61, DUSP1 |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 2 | 0.00054 | CYR61, DUSP1 |
| GO:0043408 | regulation of MAPK cascade | 2 | 0.00578 | CYR61, DUSP1 |
| GO:0042981 | regulation of apoptotic process | 2 | 0.01902 | CYR61, DUSP1 |
| GO:0050790 | regulation of catalytic activity | 2 | 0.04813 | CYR61, DUSP1 |
| GO:0010941 | regulation of cell death | 2 | 0.02167 | CYR61, DUSP1 |
| GO:0051128 | regulation of cellular component organization | 2 | 0.04404 | CYR61, DUSP1 |
| GO:1902531 | regulation of intracellular signal transduction | 2 | 0.02427 | CYR61, DUSP1 |
| GO:0043549 | regulation of kinase activity | 2 | 0.00783 | CYR61, DUSP1 |
| GO:0019220 | regulation of phosphate metabolic process | 2 | 0.02663 | CYR61, DUSP1 |
| GO:0051174 | regulation of phosphorus metabolic process | 2 | 0.02702 | CYR61, DUSP1 |
| GO:0042325 | regulation of phosphorylation | 2 | 0.02016 | CYR61, DUSP1 |
| GO:0043067 | regulation of programmed cell death | 2 | 0.01933 | CYR61, DUSP1 |
| GO:0070371 | ERK1 and ERK2 cascade | 2 | 0.00060 | CYR61, DUSP1 |
| GO:0000165 | MAPK cascade | 2 | 0.00687 | CYR61, DUSP1 |
| GO:0009888 | tissue development | 2 | 0.02669 | CYR61, DUSP1 |
| GO:0044702 | single organism reproductive process | 2 | 0.01329 | CYR61, DUSP1 |
| GO:0023014 | signal transduction by protein phosphorylation | 2 | 0.00735 | CYR61, DUSP1 |
| GO:0009719 | response to endogenous stimulus | 2 | 0.02830 | CYR61, DUSP1 |
| GO:0022414 | reproductive process | 2 | 0.01641 | CYR61, DUSP1 |
| GO:0000003 | reproduction | 2 | 0.01646 | CYR61, DUSP1 |
| GO:0051338 | regulation of transferase activity | 2 | 0.01001 | CYR61, DUSP1 |
| GO:0030162 | regulation of proteolysis | 2 | 0.00476 | CYR61, DUSP1 |
| GO:0001932 | regulation of protein phosphorylation | 2 | 0.01783 | CYR61, DUSP1 |
| GO:0031399 | regulation of protein modification process | 2 | 0.02839 | CYR61, DUSP1 |
| GO:0045859 | regulation of protein kinase activity | 2 | 0.00701 | CYR61, DUSP1 |