Skip to main content
. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: J Control Release. 2018 Oct 2;290:75–87. doi: 10.1016/j.jconrel.2018.09.025

Fig. 4.

Fig. 4.

Isothermal Titration Calorimetry experiments for (a) βSBECD (concentration: 60.0 mM) and (b) HPβCD (concentration: 60.0 mM) in LGK974 (concentration: 3.0 mM) (square) and nonlinear fitting by Wiseman Isotherm (line). (c) Thermodynamic parameters of CD-LGK974 interactions determined by isothermal titration calorimetry experiments (average stoichiometry N of the complex in solution, enthalpy ΔH°, entropy TΔS°, equilibrium constant Keq). (d) Free LGK974, LGK974 suspension in CMC/Tween 80 and CD:LGK974 solubility in PBS.