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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Lancet Respir Med. 2018 Dec 21;7(4):336–346. doi: 10.1016/S2213-2600(18)30466-1

Figure 2 – Integration of Epigenome-wide Association Study (EWAS) and Transcriptome-wide Association Study (TWAS) results for atopy.

Figure 2 –

Figure shows the -log10(FDR P-value) for DNA methylation (EWAS) in the x-axis, and for gene expression (TWAS) in the y-axis; positive values indicate hypermethylation or over-expression, and negative values indicate hypomethylation or under-expression. Pairs where both EWAS and TWAS results are non-significant (FDR P>0·01) are shown in black. Significantly hypermethylated CpGs with under-expressed corresponding genes are shown in purple (right lower quadrant; 779 CpGs, 514 genes); hypomethylated and over-expressed genes shown in dark blue (left upper quadrant; 1506 CpGs, 815 genes).