Fig. 9.

EPC transplantation reduces neuroinflammation in peri-infarct area at 7 days post- stroke. a and b, Quantitative analysis of the staining intensity of MHCII+ in the cortex and striatum revealed significant downregulation of activated MHCII+ cells in the stroke-EPC transplanted animals relative to stroke-vehicle animals across the brain (p’s < 0.001), except in SVZ (p > 0.05). EPC transplantation promoted a 78%, and 58% reduction of the estimated expression of MHC+ cells in the ipsilateral cortex and striatum, respectively relative to the ipsilateral side of the same regions of stroke-vehicle animals (p’s < 0.001). c and d Representative photomicrographs of coronal brain sections ipsilateral to injury immunostained with MHCII at 7 days post EPC transplantation. Arrows indicate positive staining for activated MHCII+ cells in the cortex (c) and striatum (d). Scale bar = 50 μm. Student t-test, p < 0.001. Data are expressed as mean ± SEM