| Key points for Chronic Granulomatous Invasive Fungal Rhinosinusitis (CGIFRS) |
|---|
| • Commonly seen in immunocompetent hosts |
| • Aspergillus flavus almost exclusive pathogen |
| • Predominates in India, Pakistan, Sudan |
| • Presence of noncaseating granulomas with fungal hyphae within Langerhans-type giant cells |
| • Dense fibrosis and minimal inflammatory reaction |
| • Surgery mainstay with radical debridement to histopathologically normal tissue |
| • Role of Antifungal therapy and treatment durations are controversial |
| • Prognosis is fair when limited to sinus; poor with extra-sinus invasion; relapse common. |
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