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Active-site inhibitors that were co-crystallised with NS2B-NS3 proteases from dengue, West Nile and Zika viruses. The actual observed ligand is highlighted in black. Inhibitor moieties that have been cleaved or hydrolysed by proteolytic digest are shown in grey. Compounds 1, 2, 4, 5 and 7 bind covalently to the catalytically active residue S135
