Skip to main content
. 2019 Mar 19;11(2):191–208. doi: 10.1007/s12551-019-00506-5

Fig. 3.

Fig. 3

Simulated kinetics of amyloid formation via homogeneous nucleation in the bulk liquid phase defined according to Eqn. Set 3 and described in terms of the total mass concentration of amyloid, CMAB (solid line – left axis) and the average degree of polymerization of amyloid in the bulk phase, iAB (dotted line – right axis). a Effect of variation in knABthe bulk phase nucleation rate constant (units M−1s−1): Thin line - knAB=1×10−3, Medium line - knAB=1×10−2; Thick line - knAB=1×10−1. b Effect of variation in kgABthe bulk phase growth rate constant (units M−1s−1): Thin line - kgAB=1×104, Medium line - kgAB=1×105; Thick line - kgAB=1×106. c Effect of variation in kS°ABthe bulk phase scission rate constant (units s−1): Thin line - kS°AB=5×10−5, Medium line - kS°AB=1×10−4; Thick line - kS°AB=1×10−3. d Effect of variation in kjAB the bulk phase amyloid end-to-end joining rate constant (units M−1s−1): Thin line - kjAB=1×102, Medium line - kjAB=1×103; Thick line - kjAB=1×104. When not specifically varied all other rate constants set as follows [knAB=1×10−2M−1s−1; kgAB=1×105M−1s−1;kS°AB=1×10−4s−1; kJAB=1×103M−1s−1]. The nucleus size is set at n = 2. (Translated and reprinted with full permission from Hirota and Hall (2019), CMC Publishing Corporation)