Fig. 7.

Schematic indicating conceptualization of amorphous aggregate as a separate phase whose liquid character is defined in terms of a mobility parameter, σ, and a density parameter, ρ. The monomer in the aggregate is assigned a molar concentration based on the phase volume (see Eqn. 9a) and rescaled second-order rate constants governing the rate at which this monomer can form amyloid are determined using the mobility parameter, σ as shown in Eqn. 9b-d. (Translated and reprinted with full permission from Hirota and Hall (2019), CMC Publishing Corporation)