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. Author manuscript; available in PMC: 2020 Mar 22.
Published in final edited form as: J Nat Prod. 2019 Mar 4;82(3):657–679. doi: 10.1021/acs.jnatprod.9b00018

Table 2.

Cytotoxicity and Hsp90 ATPase and PTP1B Inhibition of Caged Xanthones Isolated from Selected Tropical Plants and Their Analogues

no. compound source [species (part)] IC50 ref.
28 (–)-morellic acid Garcinia lateriflora (stem bark) 0.36a 51
29 (–)-11,12-dihydro-12-hydroxymorellic acid G. lateriflora 2.9a 51
30 (–)-isomoreollic acid G. lateriflora 1.9a 51
31 (–)-isogaudichaudiic acid G. lateriflora 3.2a 51
32 (–)-isogaudichaudiic acid E G. lateriflora 2.6a 51
33 (+)-pruniflorone T Cratoxylum formosum ssp. pruniflorum (roots) >5b 52
34 (–)-pruniflorone U C. formosum >5b 52
33 + (+)-pruniflorone T plus C. formosum 0.11b 52
34 (–)-pruniflorone U
35 (+)-cochinchinone C C. formosum 0.36b 52
36 epicochinchinoxanthone synthetic caged xanthone 4.1c
5.9d 		53
37 epicochinchinoxanthone-3-ether synthetic caged xanthone 3.3c
3.2d 		53
38 17,18-epoxy-epicochinchinoxanthone-3-ether synthetic caged xanthone 2.7c
0.31d 		53
39 17,18-dihydroxy-epicochinchinoxanthone-3-ether synthetic caged xanthone 1.7c
0.86d 		53
40 19-hydroxy-epicochinchinoxanthone-3-ether synthetic caged xanthone 2.5c
3.8d 		53
41 19-carbonyl-epicochinchinoxanthone-3-ether synthetic caged xanthone 1.0c
5.0d 		53
42 19-bromo-epicochinchinoxanthone-3-ether synthetic caged xanthone 0.96c
1.6d 		53
43 2-bromo-19-hydroxy-epicochinchinoxanthone-3-ether synthetic caged xanthone 0.56c
2.2d 		53
44 epiisobractatin Garcinia bracteata (leaves) 1.2e
2.1f 		54
45 13-hydroxyisobractatin G. bracteata 1.1e
2.1f 		54
46 bractatin G. bracteata 0.40e
1.0f 		54
47 3-O-methyobractatin G. bracteata 0.20e
0.80f 		54
48 DDO-6101 synthetic caged xanthone 14.3g
0.81h 		55
59
49 19-hydroxy-DDO-6101 synthetic caged xanthone 3.7g
 55
50 isomorellin (50) Garcinia hanburyi (resin) 3.3i 56
51 forbesione (51) G. hanburyi 3.5i 56
52 DDO-6306 (52) synthetic caged xanthone 0.52h
 59
53 (+)-cochinchinoxanthone Cratoxylum cochinchinense (stems)
Cratoxylum cochinchinense (roots)		 5.8a 6.6j 29
61
a

HT-29 human colon cancer cell line (μM).

b

MCF-7 human breast cancer cell line (μg/mL).

c

A549 human lung cancer cell line (μM).

d

BGC-823 human gastric cancer cell line (μM).

e

HL-60 human leukemia cell line (μM).

f

K562 human leukemia cell line (μM).

g

Hsp90 ATPase inhibition (μM).

h

HepG2 human hepatoma cell line (μM).

i

KKU-100 human cholangiocarcinoma cell line (μM).

j

Protein tyrosine phosphatase 1B (PTP1B) inhibition (μM).