Table 4.

Cytotoxicity of Sesquiterpene Lactones Isolated from Selected Tropical Plants and Their Analogues

no.	compound	source [species (part)]	IC50	ref.
74	(–)-goyazensolide	Piptocoma rufescens (leaves)	0.56a 0.86b 1.1c	93 97
75	(–)-15-deoxygoyazensolide	P. rufescens	0.26a 1.1b 1.0c	93 97
76	(–)-2′,3′-dihydro-15-deoxygoyazensolide	P. rufescens	0.58a	93
77	(+)-rufescenolide A	P. rufescens	1.9a	93
78	(–)-5-epiisogoyazensolide	P. rufescens	0.28a	93
79	(–)-lychnopholide	P. rufescens	1.4a	93
80	(+)-rufescenolide B	P. rufescens	6.6a	93
81	(+)-4,5-dihydrolychnopholide	P. rufescens	0.56a	93
82	(+)-rufescenolide C	P. rufescens	0.15a	94
83	(+)-eremantholide C	P. rufescens	>10a	93
84	(–)-ereglomerulide	P. rufescens	1.2a 4.3b 4.3c	93 97
85	(+)-rufesolide A	P. rufescens	3.0a 10.0b 8.0c	93 97
86	(–)-rufesolide B	P. rufescens	4.0a	93
87	(+)-rufesolide C	P. rufescens	1.4a	93
88	(+)-rufesolide D	P. rufescens	1.0a	93
89	parthenolide	Michelia champaca (trunk bark)	10.0b 7.5c >10d 7.5e 2.4f >10g 1.4h	91 97 105 106 108
90	parthalan	derived from 89	0.26d 1.8e	105
91	parthabine	derived from 89	0.24d 5.2e	105
92	14-nitrophenoxytriazolparthenolide	derived from 89	0.43f 1.4g	106
93	dimethylaminoparthenolide (DMAPT)	derived from 89	1.7h	108

^aHT-29 human colon cancer cell line (μM).

^bMOLM-13 human leukemia cell line (μM).

^cEOL-1 human leukemia cell line (μM).

^dHepG2 human hepatoma cell line (μM).

^eMCF-7 human breast cancer cell line (μg/mL).

^fHCT-116 human colon cancer cell line (μM).

^gA549 human lung non-small cell lung cancer cell line (μM).

^hAcute myelogenous leukemia (AML) cell line (μM).