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. 2019 Mar 17;2019:1919538. doi: 10.1155/2019/1919538

Figure 3.

Figure 3

Muscimol reduced IL-6 and IL-1β gene expression and protein production in M1 macrophages. M0 macrophages were polarized to M1 macrophages in the absence or presence of muscimol (100 μM). (a–d) qRT-PCR assays of IL-6, IL-1β, TNF-α, and CD86 mRNA. Data were normalized relative to β-actin mRNA (internal control) and presented as mean ± SD (n = 4 per group). (e–g) ELISA measurements of IL-6 (e), IL-1β (f), and TNF-α (g) secreted by M1 macrophages. Data are presented as mean ± SD (n = 4 per group). ∗ P < 0.05 compared with control cells by Wilcoxon-Mann-Whitney test.