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. Author manuscript; available in PMC: 2019 Mar 31.
Published in final edited form as: Annu Rev Nutr. 2018 May 23;38:401–429. doi: 10.1146/annurev-nutr-082117-051757

Figure 1.

Figure 1

Arsenic metabolism, target tissues, and comorbidities. Chronic As exposure has been associated with increased risk of skin lesions (melanosis, leukomelanosis, and keratosis), cardiovascular disease, hypertension (91), impaired intellectual function, inflammation, diabetes, and cancers. Ingested As accumulates in multiple tissues, including the spleen, liver, lungs, kidneys, bladder, skin, and bone marrow. (Inset) AS3MT is predominantly expressed in the liver, although AS3MT mRNA has also been detected in the kidneys, adrenal gland, bladder, heart, and brain (92). Abbreviations: AS3MT, arsenic-3-methyltransferase; DMAsV, dimethylarsinic acid; InAsIII, arsenite; MMAsIII, monomethylarsonous acid; MMAsV, monomethylarsonic acid; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine.