Table 3.

Hints for when considering salvage therapy for refractory mCRC

Patients may be better off receiving Stivarga® first with:	You want to avoid Lonsurf® in patients with:
1. Good liver function tests (Child-Pugh A and B)	1. Bone marrow reserve issues
2. Good PS	2. Liver function abnormalities (total bilirubin level >1.5 times the upper limit of normal and any AST level)
3. Exclude MI within 6 months	3. Borderline PS
4. Exclude unstable or new-onset angina
5. Exclude uncontrolled hypertension
6. Exclude ATE/VTE within 6 months

Abbreviations: AST, aspartate transaminase; ATE, aortic thromboembolism; MI, myocardial infarction; PS, performance status; VTE, venous thromboembolism.