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. 2019 Mar 27;12:2247–2258. doi: 10.2147/OTT.S185076

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© 2019 Tang et al. This work is published and licensed by Dove Medical Press Limited

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The influence of Smad2/3 on MDM2-mediated EMT in LAC cells.

Notes: Cells were transfected with siRNA for 48 hours. (A and B) The expression of Smad2/3 proteins in MDM2-overexpressing PC9 cells and H1975 cells with MDM2 interference. (C–H) The relative mRNA expression levels of Smad2/3 and EMT marker genes (E-cadherin, β-catenin, N-cadherin, and vimentin) in H1975 cells transfected with Smad2/3 siRNAs. (I, J) The protein expression levels of EMT factors (E-cadherin, β-catenin, N-cadherin, and vimentin) in Smad2 and Smad3 siRNA-transfected H1975 cells. GAPDH was used as reference control. ^*P<0.05, ^**P<0.01, and ^***P<0.001 in comparison with related control, respectively.

Abbreviations: EMT, epithelial–mesenchymal transition; LAC, lung adenocarcinoma; MDM2, mouse double minute 2; NC, negative control.