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. Author manuscript; available in PMC: 2019 Apr 22.
Published in final edited form as: Nat Neurosci. 2018 Oct 22;21(11):1551–1562. doi: 10.1038/s41593-018-0251-9

Figure 7. Selective subcortical innervation of DMT/CR+ cells in mice and human.

Figure 7

a, Low-power double immunostaining of mouse DMT for CR (brown) and orexin (Orx, black) (n = 4 mice). Small box represents the enlarged area in b.

b-c, High power images from the midline (b) and intralaminar (c) regions. Note that the orexin-positive fibers are restricted to regions populated by CR+ cells.

d-e, Low power immunostaining for CR (d) and vGluT2 (e) of the mouse DMT. f, Heat-map representing staining density shows large overlap between vGlut2 terminals and the position of CR+ cell bodies in the midline and dorsal intralaminar region.

g-i, Same images as a-c in the human thalamus (n = 4 humans). Small boxes indicate the position of high power images.

j-l, Same images as d-f in the human thalamus. Scale of the density map: 0-25 bouton/1000 μm2 (mouse) and 0-50 bouton/1000 μm2 (human). CM, central Medial thalamic nucleus; IL, intralaminar thalamic nuclei; MD, mediodorsal thalamic nuclei; PVA, paraventricular thalamic nucleus, anterior part.