Table 1.
Characteristics of the study participants, changes in glucose and BAC
| Mean (SD) | |||
|---|---|---|---|
| Study 1 (n=5) | Study 2 (n=8) | ||
| Characteristics | Before RYGB | After RYGB | RYGB 1–5 yr |
| Age, yr | 44.7 (4.6) | 45.5 (4.7) | 42.5 (8.0) |
| Weight, kg | 109.3 (15.0) | 79.1 (19.1)‡ | 80.8 (14.1) |
| BMI, kg/m2 | 42.9 (4.7) | 31.1 (6.9)‡ | 30.0 (5.2) |
| FFM, kg | 51.4 (5.8) | 46.6 (5.8)†‡ | 49.4 (5.7) |
| Co-morbidities (%)∥ | |||
| Hypertension | 40.0 | 20.0 | 0.0 |
| Hypercholesterolemia | 20.0 | 20.0 | 12.5 |
| Depression | 40.0 | 40.0 | 37.5 |
| Menopause Status (%)∥ | |||
| Pre-menopausal | 80.0 | 80.0 | 62.5 |
| Post-menopausal | 0.0 | 0.0 | 12.5 |
| Uncertain§ | 20.0 | 20.0 | 25.0 |
| Glucose Nadir, mg/dl | |||
| Placebo | −0.4 (1.0) | −1.0 (1.6) | −1.0 (1.0) |
| Alcohol | −9.6 (1.5)† | −5.5 (2.6)†‡ | −6.3 (3.4)† |
| Glucose Peak, mg/dl | |||
| Placebo | 5.6 (3.6) | 4.4 (2.3) | 5.8 (2.5) |
| Alcohol | 2.6 (2.5)† | 7.7 (4.6)† | 10.7 (4.6)† |
| Alcohol-related variables | |||
| Peak BAC (g/L) | 0.58 (0.09) | 1.23 (0.2)‡ | 1.10 (0.17) |
| Time to peak BAC (min)* | 36.1 (15.8) | 15.0 (0.0)‡ | 15.0 (0.0) |
| Area under the BAC-time curve (g·l−1 min) | 99.3 (6.7) | 173.5 (30.5)‡ | 151.2 (7.2) |
SD = standard deviation; RYGB = Roux-en-Y gastric bypass; BMI = Body mass index (calculated as weight in kilograms divided by height in meter squared); FFM = fat free mass. BAC = blood alcohol concentration; % = percentage
*
From the time of the first sip of the drink, which was ingested over 10 min.
§
Three patients had hysterectomy. One was on hormone replacement treatment.
∥
The present study is underpowered to detect clinically meaningful difference
Values are represented in means (SD).
†
different from placebo (P < .01).
‡
different from Before RYGB (P <.05)