Faro 1988.

Methods	Design: randomised double‐blinded No. eligible: not stated No. randomised: 114 No. analysed: 100 Drop‐outs/withdrawals: 14 (5 in vaginal group had abdominal surgery, 1 had operation cancelled, 6 received additional antibiotics, 2 received inappropriate doses) Years of recruitment: not stated Setting: centre not stated but study took place in the United States
Participants	Inclusion criteria: women scheduled for elective vaginal hysterectomy. Exclusion criteria: not stated Age: mean 32 to 33 years Type of hysterectomy: vaginal
Interventions	Treatment 1: 4 grams mezlocillin Treatment 2: 2 grams cefoxitin Route: IV Single/multiple doses: multiple Timing of doses: first dose within 1 hour of surgery, second dose on return from recovery room, and third dose 6 hours later
Outcomes	Postoperative infection, early and early + late Pelvic infection Need for therapeutic antibiotics Length of hospital stay Follow‐up: 6 weeks
Funding	Miles Laboratories
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Computer‐generated ... schedule"
Allocation concealment (selection bias)	Unclear risk	Method not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blind ‐ no details given
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Imbalance in proportions of exclusion (10 vs 4) but reasons for exclusion not stated by treatment group
Selective reporting (reporting bias)	Unclear risk	Insufficient information to make a conclusive judgement
Other bias	Unclear risk	Insufficient information to make a conclusive judgement