Jaffe 1985.

Methods	Design: randomised placebo‐controlled No. eligible: not stated No. randomised: 98 No. analysed:90 Drop‐outs/withdrawals: 8 (2 for positive preoperative urine culture in treatment group; 3 for positive preoperative urine culture, 2 for malignancy, and 1 for protocol mistake in placebo group) Years of recruitment: not stated Setting: Meir General Hospital, Israel
Participants	Inclusion criteria: women admitted for elective abdominal hysterectomy for benign condition Exclusion criteria: antibiotics in previous 2 weeks, allergy to study drugs Age: 46 to 48 years Type of hysterectomy: abdominal
Interventions	Treatment 1: 15 mL co‐trimoxazole (antiprotozoal): 12000 mg sulphamethoxazole, 240 mg trimethoprim Control: placebo Route: IV Single/multiple doses: single Timing of doses: infused during last 30 minutes before surgery
Outcomes	Urinary tract infection Postoperative fever Adverse effects (narrative data only) Hospital length of stay
Funding	Not stated
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	States "randomly assigned" ‐ no other details
Allocation concealment (selection bias)	Unclear risk	Method not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	States that "the placebo group received the placebo with the saline in the same manner"; no details reported on outcome assessor or evaluation of participants
Incomplete outcome data (attrition bias) All outcomes	High risk	Proportions of withdrawals and reasons for withdrawals not balanced across treatment groups
Selective reporting (reporting bias)	Low risk	Data available on all prespecified outcomes
Other bias	Low risk	Baseline demographic characteristics similar between treatment groups