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. 2019 Mar 29;21(5):429–441. doi: 10.1016/j.neo.2019.03.002

Figure 2.

Figure 2

PDHA1 is the downstream target of SIRT2/cMYC.

(A) HuCCT1 and RBE cells were treated with 0, 25, or 50 μm Tm and subjected to western blotting. (B & C & D & E) HuCCT1 and RBE cells were transfected with siRNA of cMYC, plasmids of cMYC, CPI-613, Tm, or siRNA of PDHA1, respectively, and subjected to western blotting. (F) The OCRs were detected at different time points. The OCR was under oligomycin, carbonyl cyanide-m-chlorophenylhydrazone (FCCP), and antimycin A/rotenone treatments, respectively. Data represent mean ± SEM, n ≥ 3.