Table 4.
Cytokine and immunoglobulin expression normalized to uninfected controls (+1. S.E.). Results are shown as log-fold-change by cytokine type and tissue (S = spleen, I = intestine).
| Type | Gene | Tissue | Day 1 |
Day 7 |
Day 14 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | |||||||||||
| I | II | Mixed | I | II | Mixed | I | II | Mixed | |||
| Pro-inflammatory | TNF-a | S | 0.02 (±0.01) | 0.01 (±0) | −0.02 (±0.01) | 0 (±0.03) | 0.05 (±0.02) | 0.03 (±0.01) | −0.01 (±0.04) | −0.02 (±0.02) | 0.02 (±0.01) |
| I | −0.02 (±0.01) | −0.01 (±0.02) | 0.05 (±0.02) | 0.02 (±0.02) | −0.03 (±0.01) | −0.03 (±0.01) | 0.01 (±0) | −0.01 (±0.01) | 0 (±0.02) | ||
| IL-1B | S | 0.06 (±0.03) | 0.07 (±0.02) | 0 (±0.03) | 0.03 (±0.02) | 0.07 (±0.02) | 0.08 (±0.02) | 0 (±0.02) | 0.02 (±0) | 0.03 (±0) | |
| I | −0.06 (±0.01) | −0.06 (±0.01) | −0.04 (±0) | −0.03 (±0) | −0.02 (±0) | 0 (±0.01) | −0.03 (±0) | −0.03 (±0) | −0.02 (±0) | ||
| IFN-g | S | 0.03 (±0.01) | 0.04 (±0.01) | 0.03 (±0.02) | 0.02 (±0.02) | 0.02 (±0.01) | 0.08 (±0.01) | 0.02 (±0.02) | 0.02 (±0.01) | 0.08 (±0.01) | |
| I |
−0.02 (±0.02) |
−0.05 (±0.03) |
−0.04 (±0.01) |
−0.02 (±0.01) |
0.02 (±0.01) |
0.03 (±0.01) |
0.11 (±0) |
0.18 (±0.01) |
0.17 (±0) |
||
| Inflammatory and regulatory | IL-6 | S | −0.01 (±0.02) | −0.01 (±0.02) | −0.04 (±0.02) | −0.02 (±0.02) | 0.01 (±0.01) | 0.06 (±0.02) | 0.09 (±0) | −0.05 (±0.03) | 0.1 (±0.03) |
| I | −0.01 (±0.01) | 0 (±0.02) | 0.06 (±0.02) | 0.03 (±0.01) | −0.01 (±0.01) | 0 (±0.01) | 0.04 (±0.01) | 0.14 (±0.02) | 0.13 (±0.01) | ||
| IL-8 | S | 0.03 (±0.01) | 0.01 (±0.01) | 0.01 (±0.01) | 0.03 (±0.03) | 0.06 (±0.02) | 0.04 (±0.01) | 0.01 (±0.01) | 0.01 (±0.01) | 0.05 (±0) | |
| I |
0.01 (±0) |
−0.03 (±0.01) |
−0.01 (±0.01) |
−0.01 (±0.01) |
0.01 (±0) |
0.01 (±0.01) |
0.08 (±0.01) |
0.1 (±0.01) |
0.09 (±0) |
||
| Regulatory | IL-10 | S | 0.04 (±0.02) | 0.05 (±0.03) | 0 (±0.02) | 0.01 (±0.03) | 0.02 (±0.02) | 0.03 (±0.02) | 0.13 (±0.01) | 0.09 (±0.01) | 0.18 (±0) |
| I | −0.02 (±0.01) | −0.03 (±0.01) | −0.02 (±0.01) | −0.07 (±0.02) | −0.07 (±0.01) | 0.01 (±0.01) | −0.03 (±0.02) | 0.03 (±0.01) | 0.04 (±0) | ||
| TgF B | S | 0.08 (±0.04) | 0.1 (±0.01) | 0.08 (±0) | 0.01 (±0.02) | 0.03 (±0.01) | 0.01 (±0.01) | 0.02 (±0.01) | 0 (±0.01) | 0.03 (±0.01) | |
| I |
−0.01 (+0.01) |
0 (+0.01) |
−0.01 (+0.01) |
0.03 (+0.01) |
0.05 (+0) |
0.05 (+0.01) |
0.04 (+0) |
0.06 (+0.01) |
0.06 (+0.03) |
||
| Reference | Actin | S | 0.08 (+0.02) | 0.11 (+0) | 0.04 (+0.03) | 0.01 (+0.03) | 0.02 (+0.01) | 0.03 (+0) | 0.02 (+0.02) | 0.03 (+0.01) | 0.05 (+0.01) |
| I | −0.01 (+0.01) | 0.02 (+0.01) | 0 (+0) | 0.03 (+0.01) | 0.03 (+0.02) | 0.03 (+0) | −0.01 (+0) | 0.02 (+0.01) | 0.05 (+0) | ||