Table 1.
Baseline Clinical Characteristics of 129 Patients With MDR TB
| Total (n = 129) | FQ-S MDR TB (n = 90, 69.8%) | FQ-R MDR TB (n = 39, 30.2%) | P | |
|---|---|---|---|---|
| Age, y | 39.7 (17–86) | 38.3 (19–86) | 40.0 (17–86) | .955 |
| Male gender | 79 (61.2) | 54 (60.0) | 25 (64.1) | .660 |
| BMI, kg/m2 | 20.7 (13.5–41.7) | 20.6 (13.5–28.7) | 21.0 (16.5–41.7) | .361 |
| Current or former smoker | 54 (41.9) | 36 (40.0) | 18 (46.2) | .515 |
| Comorbidities | ||||
| Diabetes | 28 (21.7) | 19 (21.1) | 9 (23.1) | .804 |
| HTN | 19 (14.7) | 16 (17.8) | 3 (7.7) | .138 |
| Chronic liver diseases | 9 (7) | 5 (5.6) | 4 (10.3) | .452 |
| Chronic renal failure | 8 (6.2) | 8 (8.9) | 0 | .105 |
| Respiratory disease | 7 (5.4) | 6 (6.7) | 1 (2.6) | .674 |
| Malignancy | 16 (12.4) | 13 (14.4) | 3 (7.7) | .389 |
| Immunosuppression | 2 (1.6) | 2 (2.2) | 0 | 1.0 |
| Previous TB treatment history | ||||
| None | 59 (45.7) | 50 (55.6) | 9 (23.1) | .001 |
| Firstline only | 47 (36.4) | 35 (38.9) | 12 (30.8) | .379 |
| Second-line | 23 (17.8) | 5 (5.6) | 18 (46.2) | <.001 |
| Laboratory test, mean ± SD | ||||
| Hb, g/dL | 13.3 ± 2.07 | 13.2 ± 2.14 | 13.6 ± 1.89 | .348 |
| Protein, g/dL | 7.0 ± 0.65 | 7.0 ± 0.67 | 7.2 ± 0.56 | .128 |
| Albumin, g/dL | 4.1 ± 0.57 | 4.1 ± 0.62 | 4.1 ± 0.44 | .637 |
| Cholesterol, mg/dL | 161.3 ± 34.91 | 161.3 ± 36.71 | 161.3 ± 30.83 | .996 |
| Radiographic finding | ||||
| Cavity lesions | 58 (45.0) | 35 (38.9) | 23 (59.0) | .035 |
| Bilateral disease | 69 (53.5) | 43 (47.8) | 26 (66.7) | .048 |
| Positive AFB smear at treatment initiation | 56 (43.4) | 30 (33.3) | 26 (66.7) | <.001 |
| Drug resistance pattern | ||||
| SLID-S, FQ-S MDR | 85 (65.9) | 85 (94.4) | 0 | |
| FQ-S, SLID-R, MDR (pre-XDR) | 5 (3.9) | 5 (5.6) | 0 | |
| SLID-S, FQ-R, MDR (pre-XDR) | 28 (21.7) | 0 | 28 (71.8) | |
| XDR | 11 (8.5) | 0 | 11 (28.2) |
Data are presented as No. (%), mean ± SD, or median (range).
Abbreviations: AFB, acid-fast bacilli; BMI, body mass index; FQ, fluoroquinolone; HTN, hypertension; MDR TB, multidrug-resistant tuberculosis; R, resistant; S, sensitive; SLID, second-line injectable drug; TB, tuberculosis; XDR, extensively drug-resistant.