Table 4. Comparison of the pharmacokinetic parameters of valnemulin hydrogen tartrate Form I with those of valnemulin hydrochloride after oral administration of 10 mg/kg to pigs.
| Valnemulin forms | Target animals | Dose (mg/kg) | Cmax (mg/L) | T1/2 (h) | Tmax (h) | AUClast (h·mg / L) | Ref. |
|---|---|---|---|---|---|---|---|
| Valnemulin hydrochloride | Pigs | 10 | 0.59 ± 0.08 | 2.20 ± 0.19 | 1.98 ± 0.21 | 3.12 ± 0.39 | [23] |
| Valnemulin hydrogen tartrate Form I | Pigs | 10 | 0.60 ± 0.05 | 1.92 ± 0.01 | 2.12 ± 1.5 | 4.64 ± 0.59 | This work |
AUClast, the area under the concentration–time curve from time zero to the last measurable concentration.