Table 2. Pharmacokinetic parameters of enrofloxacin following intravenous and peroral administrations.
| Parameters | Unit | IV | PO |
|---|---|---|---|
| T1/2 | h | 12.84 ± 1.40 | 25.84 ± 1.40 |
| Tmax | h | 0.22 ± 0.10 | 0.65 ± 0.12 |
| Cmax | µg/mL | 6.74 ± 0.03 | 3.82 ± 0.59 |
| AUC0–24 | h·µg/mL | 21.13 ± 0.90 | 20.84 ± 5.00 |
| F | % | - | 98.60 ± 8.90 |
Values are means ± standard deviation of 8 samples. Values were determined by using WinNonlin software.
IV, intravenous; PO, peroral; T1⁄2, elimination half-life; Tmax, time of maximum concentration; Cmax, maximum concentration after administration; AUC0–24, area under the serum concentration-time curve from time zero to 24 h; F, bioavailability.