Table 4. Pharmacokinetic/pharmacodynamic integration of enrofloxacin in chicken after IV and PO administrations (10 mg/kg b.w.).

Parameters	IV	PO
AUC0–24/MIC50 (h)	42.26 ± 0.30	41.68 ± 0.10
Cmax/MIC50	13.48 ± 0.70	7.64 ± 0.20

Values are means ± standard deviation. Recommended dosage: AUC_0–24/MIC₅₀ ≥ 100–125; C_max/MIC₅₀ ≥ 8–10.

IV, intravenous; PO, peroral; b.w., body weight; AUC_0–24, area under the serum concentration-time curve from time zero to 24 h; MIC₅₀, minimum inhibitory concentration values that inhibit the growth of at least 50% of isolates; C_max, maximum concentration after administration.