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Tumor‐derived mutations mapped onto crystal structures of BDs. (A) Tumor‐derived mutations were mapped onto the available crystal structure of BD2 of PBRM1 (Filippakopoulos et al., 2010). (B) BD4* mutation was mapped onto the available crystal structure of BD4 of PBRM1 (Filippakopoulos et al., 2010). (C) The location of the critical N739 was mapped onto the available crystal structure of BD5 of PBRM1 (Filippakopoulos et al., 2010).
