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. 2019 Feb 15;13(4):873–893. doi: 10.1002/1878-0261.12443

Figure 3.

Figure 3

Forkhead box transcription factor M1 was correlated with DOT1L‐mediated H3K79me2 modification. (A) Representative genome‐browser view of H3K4me3, H3K36me3, H3K79me2 ChIP‐Seq for Homo sapiens colon colorectal cancer cell line HCT116 and monocytes CD14+ cells at the FOXM1 on chromosome 12. The Y‐axis indicated the peak height and the X‐axis indicated the genomic location. (B) and (D) The correlation between FOXM1, MLL1 (histone methyltransferase of H3K4me3), and DOT1L (histone methyltransferase of H3K79me2) transcripts in patients with pancreatic cancer was examined analyzing 131 patients (GSE62165). R 2 = 0.03541, P = 0.0314 (B); R 2 = 0.1615, P < 0.0001 (D). (C) and (E) The correlation between FOXM1, MLL1, and DOT1L transcripts in patients with colon cancer was examined analyzing 246 colon cancer patients (GSE44076). R 2 = 0.00009682, P = 0.8780 (C); R 2 = 0.3920, P < 0.0001 (E). (F) and (G) The correlation of DOT1L and FOXM1 was examined analyzing the peripheral blood of 7 pancreatic cancer patients and 8 colon cancer patients. R 2 = 0.3361, P = 0.1724 (F); R 2 = 0.2556, P = 0.2012 (G).