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. 2019 Feb 9;13(4):909–927. doi: 10.1002/1878-0261.12446

Figure 4.

Figure 4

Impact of LncKLHDC7B silencing on the TNBC immunomodulatory phenotype. (A) Validation of LncKLHDC7B and KLHDC7B expression in a panel of breast cancer cell lines. (B) Expression levels of LncKLHDC7B in immunomodulatory phenotype (HCC1187) of breast cancer cell line after silencing by shRNA system. KLHDC7B coding gen expression is affected by LncKLHDC7B silencing. All data are shown as the mean ± SD of at least three independent experiments. Student's t test was performed to determine significance *P < 0.05, **P < 0.01, ***P < 0.001 of NC vs shRNA. (C) Heatmap from transcripts altered by LncKLHDC7B silenced. The microarray was performed in triplicate for the NC condition (blue bar) and shRNA‐1 (yellow bar). Red represents elevated and green down‐regulated expression. (D) Prediction of interactions between lncRNA and mRNA targets sub‐expressed by the silencing of the LncKLHDC7B. Continuous and dotted lines represent a medium and high interaction, respectively.