Table 1.
Missense, truncating, and frameshift mutations (putative driver) in DNA damage response and repair genes identified in 528 colorectal cancer cases reported in The Cancer Genome Atlas Colon Adenocarcinoma (COAD) and Rectal Adenocarcinoma (READ) PanCancer Atlas datasets (Liu et al., 2018). Asterisk (*) indicates methylation data acquired from the TCGA‐COADREAD Provisional dataset
| Gene | Cases affected (%) |
|---|---|
| TRP53 | 92 (17.4) |
| ATM | 18 (3.4) |
| BRCA2 | 10 (1.9) |
| TP53BP1 | 9 (1.7) |
| MSH6 | 7 (1.3) |
| ATR | 7 (1.3) |
| MTOR | 5 (0.9) |
| SMARCB1 | 4 (0.8) |
| ATRX | 3 (0.6) |
| BARD1 | 3 (0.6) |
| BLM | 3 (0.6) |
| MSH3 | 3 (0.6) |
| BRIP1 | 2 (0.4) |
| FANCA | 2 (0.4) |
| RAD50 | 2 (0.4) |
| EPC2 | 1 (0.2) |
| ERCC4 | 1 (0.2) |
| MLH1 | 1 (0.2) |
| 37 (10.3)* | |
| MSH2 | 1 (0.2) |
| PMS2 | 1 (0.2) |
| RAD21 | 1 (0.2) |
| RAD21L1 | 1 (0.2) |
| RAD51C | 1 (0.2) |
| SMC1A | 1 (0.2) |
| XRCC2 | 1 (0.2) |
| XRCC3 | 1 (0.2) |