Figure 3.

Differential analysis of protein abundance and overrepresented pathways in the proteomic analysis. (A) Protein abundance differential analysis in two comparisons: tumors from diabetics versus tumors from nondiabetics and normal colonic mucosa from diabetes versus normal colonic mucosa from nondiabetics. In light red, up‐ and downregulated proteins with a P‐value <0.05, and in dark, red proteins with P‐value <0.05 and FC > 1.2. (B) Networks generated from upregulated proteins (in red, FC > 1.2, P‐value <0.05) in diabetic patients’ tumor and normal colonic mucosa. (C) Differences in overrepresented KEGG pathways in tumors and normal colonic mucosa when comparing diabetic vs nondiabetic patients.