Table 1.
Functional aspects of human adipose-derived stem/stromal cells derived from different adipose depots
| ASC depot origin | Species | Metabolic status of subjects | Gender | Sample number (n) | Functional aspects of ASC | Publications |
| SC and VC | Human | Non-obese | Male and female | 18 | Proliferation: SC > VC | Baglioni et al[85], 2012 |
| Adipogenic potential: SC > VC | ||||||
| Adiponectin secretion by ASC-derived adipocytes: SC > VC | ||||||
| Lipolysis susceptibility of ASC-derived adipocytes: VC > SC | ||||||
| SC, PP, VC | Human | Morbidly obese | Female | 12 | Adipogenic potential: PP > SC > VC | Silva et al[86], 2017 |
| IL-6, IL-8, MCP-1, G-CSF secretion: VC > SC = PP | ||||||
| PAI-1 secretion: SC=PP > VC | ||||||
| Adiponectin secretion by ASC-derived adipocytes: PP > SC = VC | ||||||
| SC e VC | Human | Obese | Male and female | 29 | Proliferation: SC > VC | van Harmelen et al[131], 2004 |
| Adipogenic potential: SC = VC | ||||||
| SC and VC | Human | Non-obese | Female | 5 | Surface markers (CD31-, CD34-, CD45-, CD73+, CD90+, CD105+): SC = VC | Kim et al[151], 2016 |
| Proliferation: SC > VC ; | ||||||
| Adipogenic potential: SC > VC ; | ||||||
| Genetic pattern: SC ≠ VC | ||||||
| Lipid biosynthesis and metabolism genes expression: VC > SC | ||||||
| DNA-dependent transcription: SC > VC | ||||||
| SC and VC | Mice and human | Non-obese and obese | Male and female | 198 (human) | Genome-wide expression profiles (including embrionic development and pattern specification genes): SC ≠ VC | Gesta et al[152], 2006 |
| SC, VC | Human | Lean and obese | Male and female | 12 | Proliferation: SC > VC | Tchkonia et al[153], 2007 |
| Adipogenic potential: SC > VC mesenteric > VC omentum | ||||||
| Induced-apoptosis susceptibility VC > SC | ||||||
| Genome-wide expression profiles (including early development genes): SC ≠ VC | ||||||
| SC and VC | Human | Obese | Female | 8 | MCP-1, IL-6, IL-8, CCL-5 secretion: VC > SC | Zhu et al[154], 2015 |
| SC and VC | Human | Non-obese | Male and female | 15 | MCP-1, eotaxin, IL-1ra, IL-6, GM-CSF, VEGF secretion: VC > SC | Perrini et al[155], 2013 |
| SC and PP | Human | Non-obese and obese | Male | 8 | Proliferation: SC > PP | Fernández et al[156], 2010 |
| Adipogenic potential: PP > SC | ||||||
| SC and VC | Human | Lean and obese | Female | 14 | Adipogenic potential: SC > VC | Hauner et al[159], 1988 |
| SC and VC | Human | Not stated | Not stated | Not stated | Adipogenic potential: SC > VC | Adams et al[160], 1997 |
| SC and VC | Human | Non-obese and obese | Male and female | 12 | Adipogenic potential: SC > VC | Niesler et al[161], 1998 |
| Susceptibility to induced apoptosis: VC > SC | ||||||
| SC and VC | Human | Non-obese and obese | Male and female | Not stated | Adipogenic potential: SC > VC | Digby et al[162], 2000 |
| SC, VC | Human | Obese | Male and female | 16 | Adipogenic potential: SC > VC mesenteric > VC omentum | Tchkonia et al[163], 2002 |
| SC, VC | Human | Obese | Male and female | 18 | Adipogenic potential: SC > VC omentum | Tchkonia et al[164], 2005 |
| Resistance to induced apoptosis: SC > VC omentum | ||||||
| Proliferation: SC = VC mesenteric > VC omentum | ||||||
| SC, VC | Human | Overweight and obese | Male and female | 31 | Adipogenic potential: SC > VC | Tchkonia et al[165], 2006 |
| Resistance to induced apoptosis: SC > VC mesenteric > VC omentum | ||||||
| SC and VC | Human | Not stated | Not stated | 21 | Proliferation: SC = VC | Toyoda et al[166]2009 |
| Adipogenic and osteogenic potential: SC > VC | ||||||
| SC and VC | Mice | Non-obese and obese | Not stated | Not stated | Proliferation: SC > VC | Macotela et al[167], 2012 |
| Adipogenic potential: SC > VC | ||||||
| SC and VC | Mice | Not stated | Male | Not stated | Adipogenic potential: SC > VC | Meissburger et al[168], 2016 |
| SV and VC | Mice | High-fat diet | Male and female | Not stated | Proliferation in response to high-fat diet: SC > VC | Joe et al[169], 2009 |
| Adipogenic potential: SC > VC | ||||||
| SC and VC | Human | Non-obese and obese | Male and female | 18 | Adipogenic potential: SC = VC | Shahparaki et al[170], 2002 |
| SC and VC | Human | Non-obese | Male and female | 13 | ASC-derived adipocytes C/EBP, AP-2 and adiponection expression: SC > VC | Perrini et al[171], 2008 |
| Adiponectin secretion of ASC-derived adipocytes: VC > SC | ||||||
| Stimulated glucose uptake ASC-derived adipocytes: VC > SC | ||||||
| SC e VC | Mice | Lean | Male | Not stated | MMP14 expression: SC = VC | Tokunaga et al[172], 2014 |
| MMP8 and MMP13: VC > SC |
ASC: Adipose-derived stem/stromal cells; G-CSF: Granulocyte colony-stimulating factor; GM-CSF: Granulocyte-Macrophage colony-stimulating factor; IL: Interleukine; MCP-1: Monocyte chemoattractant protein-1; MMP: Matrix metaloproteinase; PP: Preperitoneal; SC: Subcutaneous; VEGF: Vascular endothelial growth factor; VC: Visceral.