Fig. 2.

High expression of FA2H correlates with better survival of gastric cancer patients.

a, b) Kaplan-Meier curves for overall survival of 117 gastric cancer samples according to the expression of FA2H (a) or GLI1 (b). Cohort was stratified by the immunohistochemistry definition (− indicates negative, + indicates positive). The color-shaded areas around the estimated survival curves represent the 95% confidence bands.

c) Forest Plot of Hazard Ratios (HR) between low and high expression of FA2H by patient subgroups. Estimates with 95% confidence intervals (95% CI) for overall survival (OS) of 117 cases of gastric cancer were stratified according to different clinical factors. The area of the blue squares centred on the estimated HR for overall population and individual subgroups are proportional to their corresponding percentage weights. The vertical dashed line represents the HR for overall population, while the vertical solid line represents no effect (HR = 1).

d) Kaplan-Meier curve for overall survival of 300 gastric cancer samples from the public microarray dataset GSE62254 [26] according to the expression of FA2H. Cohort was stratified by the median value of FA2H relative expression (− indicates below median expression of FA2H, + above median). The color-shaded areas around the estimated survival curves represent the 95% confidence bands.

e) Column scatter plots validating the difference of FA2H expression between human gastric cancer tumors and normal tissues based on three public microarray datasets [GSE13911 [23], GSE29272 [24] and GSE79973 [25]].

*, P < 0·05; **, P < 0·01; ***, P < 0·001. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)