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. 2019 Feb 7;41:50–61. doi: 10.1016/j.ebiom.2019.01.065

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — CD36 is implicated in oxLDL-induced DPP4 up-regulation.

Bone marrows isolated from wild-type (WT) or Cd36^−/− mice were used for the induction of BMMs. The expressions of DPP4 on both WT and Cd36^−/− BMMs were detected by imaging flow cytometry after 24-h treatment with 25 μg/mL oxLDL. Statistical analysis (A), representative images (B), histograms (C), and dot plots (D) are shown. *, p < .05 compared with UT; #, p < .05 compared with WT. E, Lipid dysregulation in obesity and atherosclerosis induces DPP4 up-regulation through oxLDL and CD36/TLR4/TRIF pathway. DPP4, dipeptidyl peptidase 4; oxLDL, oxidized low density lipoprotein; TLR4, Toll-like receptor 4; TRIF, Toll/IL-1R domain-containing adaptor-inducing IFN-β.