. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2018 Nov 30;103(5):1151–1157. doi: 10.1016/j.ijrobp.2018.11.049

Table 2.

Comparison of parameningeal local failure on recent COG/IRSG studies

Study	Cyclophosphamide dose per cycle (g/m2)	Cumulative alkylating agent dose^*	Local failure for PM-RMS
IRS-IV¹⁴	2.2^**	26.4	16%
IRS-V (D9803)⁴	2.2	25.1-30.8	19%
ARST05311¹⁶	1.2	8.4-16.8	28%
MSK (current study)
Cohort A
Cohort B	1.2	10 (median)	33.5%
	2.2	24 (median)	8.8%

In cyclophosphamide equivalents

^**

Or 9g/m² of ifosfamide