Table 4b.

Predicted metabolizer phenotypes based on CYP2D6 diplotypes (allele combinations). Metabolizer phenotypes are determined by activity scores in Table 4a. PM, activity scores=0; IM: activity scores=0.5–1; NM: activity scores= >1 to 2; UM: activity scores >2.

	*1	rs16947 (H3)	rs16947 and rs5758550(H2)	rs5758550 (H1)	*3, *4, *6, *5 and other null allelese	*9, *10, *17 and other reduced activity allelesf	*1×2
*1	NM
rs16947 (H3)	NM	IM
rs16947 and rs5758550 (H2)	NM	NM	NM
rs5758550 (H1)	UM	UM	UM	UM
*3, *4, *6, *5 and other null alleles	IM	IMa	IM	IM or NMb	PM
*9, *10, *17 and other reduced activity alleles	NM	IM or NMc	NM	NM or UMd	IM	IM
*1 × 2	UM	NM	UM	UM	NM	NM	UM

Note:

^a.Because H3 is on the same haplotype as *6 in AFR, the activity score for *6 and H3 combination is 1 (H3e/*1, IM) for AFR. The activity score in other populations or H3 with other null allele combinations in AFR are 0.5 (IM).

^b.Because H1 is on the same haplotype as *4 and *3 in EUR, the activity score for combination of *4 or *3 and H1 is 1(IM, H1b/*1 or H1c/*1) in EUR. H1 has 25% and 60% chance of being on the same haplotype with *4 in AFR and AMR, respectively, the activity score for combination of *4 and H1 could be 1 or 2 in AFR or AMR. The activity score for H1 and *4 or *3 combination in ASN or for H1 and other null allele combinations are 2 (NM).

^c.Because H3 is on the same haplotype as *17 in AFR, the activity score for combination of H3 and *17 is 1.25 (NM, H3a/*1) in AFR. The activity score in other populations or the combination of H3 and other reduced activity alleles are 1 (IM).

^d.Because H1 is on the same haplotype as *10 in ASN, the activity score for combination of H1 and *10 is 2 (NM, H1d/*1) in ASN. The activity score in other populations or the combination of H1 with other reduced activity alleles are 2.5 (UM).

^e.Other null alleles listed in CPIC guidelines, including *5, *7, *8, *11, *12, *13, *14, *15, *16, *18, *19, *20, *21, *31, *36, *38, *40, *42, *44, *47, *51, *56, *57 and *62.

^f.Other reduced activity alleles listed in CPIC guideline, including *49, *50, *54, *55, *59, *69 and *72.