Table 1.

Pharmacokinetic parameters for each antimicrobial agent from published studies carried out in children (mean±standard deviation).

	Amoxicillin	Cefuroxime axetil	Cefotaxime
V/F (L/Kg)	1.44 ± 0.37	0.72 ± 0.14	0.295 ± 0.059
K (h-1)	0.276 ± 0.137	0.5 ± 0.1	0.75 ± 0.15
Ka (h-1)	1.77 ± 0.99	0.43 ± 0.11	-
fu	0.8	0.6	0.6
Reference	[14,15]	[16]	[17-19]

V/F: volume of distribution/drug bioavailability, K: elimination constant rate, KA: absorption constant rate, fu: unbound fraction