Table 3.
Activity of the antibiotic studied against H. influenzae isolates from AOM in children in the pre-vaccination period (1998-1999, n=146 isolates), and in the post-vaccination period (2011, n=48 isolates).
| % of strains inhibited at MIC (mg/L) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Antimicrobial | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | |
| Amoxicillin | Pre-PCV7 | 54.1 | 18.5 | 6.8 | 1.4 | 19.2 | ||||||||
| Post-PCV7 | 62.5 | 18.7 | 6.3 | 4.2 | 8.3 | |||||||||
| Amoxicillin/clavulanate | Pre-PCV7 | 0.7 | 0.7 | 0.7 | 5.5 | 43.1 | 28.7 | 15.1 | 5.5 | |||||
| Post-PCV7 | 4.2 | 60.4 | 27.1 | 8.3 | ||||||||||
| Cefuroxime axetil | Pre-PCV7 | 7.5 | 11.0 | 47.3 | 22.6 | 10.3 | 1.4 | |||||||
| Post-PCV7 | 2.1 | 25.0 | 47.9 | 25 | ||||||||||
| Cefotaxime | Pre-PCV7 | 99.2 | 0.3 | 0.3 | 0.3 | |||||||||
| Post-PCV7 | 81.3 | 18.8 | ||||||||||||