Comparison 2. Comparison between two types of antibiotics.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Recurrence of symptomatic UTI	3	317	Risk Ratio (M‐H, Random, 95% CI)	0.60 [0.40, 0.92]
1.1 Nitrofurantoin versus cotrimoxazole	2	157	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.35, 0.92]
1.2 Cotrimoxazole versus cefadroxil	1	46	Risk Ratio (M‐H, Random, 95% CI)	1.79 [0.33, 9.70]
1.3 Cotrimoxazole versus cefprozil	1	55	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.20, 2.39]
1.4 Cefadroxil versus cefprozil	1	59	Risk Ratio (M‐H, Random, 95% CI)	0.39 [0.09, 1.71]
2 Repeat positive urine culture	3	279	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.21, 4.34]
2.1 Nitrofurantoin versus trimethoprim	1	120	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.19, 0.56]
2.2 Nitrofurantoin versus cefixime	1	57	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.24, 7.48]
2.3 Nalidixic acid versus cotrimoxazole	1	102	Risk Ratio (M‐H, Random, 95% CI)	2.27 [1.25, 4.13]
3 Microbial resistance to prophylactic drugs	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Nitrofurantoin versus cotrimoxazole	2	96	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.31, 0.92]
4 Adverse events	3		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
4.1 Cotrimoxazole versus cefprozil	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 Nitrofurantoin versus cefixime	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.3 Nitrofurantoin versus trimethoprim	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.4 Discontinuation of treatment due to adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]