Savage 1973.

Methods	Study design: parallel RCT Recruitment period: 1969 to 1970 Duration of follow‐up: mean of 44 months (treatment cessation 10 weeks)
Participants	Country: UK Setting: single centre Girls with a criteria for initial UTI diagnosis was > 100,000 CFU/mL on 3 consecutive occasions VUR: 19 Number: treatment group (29); control group (34) Mean age: treatment group (6 years 3 months); control group (5 years 10 months) Sex: all girls Exclusion criteria: past history of UTI or "unwell"
Interventions	Treatment group Antibiotic treatment according to sensitivities Nitrofurantoin: 4 mg/kg/d for 10 weeks after 2 weeks acute treatment OR Cotrimoxazole: 20 to 40 mg TMP; 100 to 200 mg SMX twice daily for 10 weeks after 2 weeks acute treatment Control group No treatment for 10 weeks after 2 weeks of acute treatment with ampicillin
Outcomes	Number of symptomatic UTI Number of repeat positive cultures
Notes	Funding source: "This work was supported by a grant from the Secretary of State for Scotland"
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias)	Unclear risk	States allocated by random numbers except for those with history of past UTI
Blinding of participants and personnel (performance bias) All outcomes	High risk	No blinding used
Blinding of outcome assessment (detection bias) All outcomes	High risk	No blinding used
Incomplete outcome data (attrition bias) All outcomes	Low risk	Loss to follow‐up accounted for and described
Selective reporting (reporting bias)	Low risk	Appropriate primary outcome (symptomatic UTI)
Other bias	Unclear risk	Many methodology details missing