Figure 1.

Nor1 knockout mice display increased β-cell mass. A, images show representative insulin immunostaining in WT, Nor1^−/− and Nur77^−/− pancreata. B, quantification of cross-sectional β-cell areas. Results are represented as -fold-change over WT animals. n = 6 for each genotype. C, β-cell proliferation was evaluated by counting the number of Ki67-positive nuclei. n = 4 for each genotype. D, quantification of cross-sectional α-cell area in WT and Nor1 knockout mice. n = 4 for each genotype. All results are represented as means ± S.E.; *, p < 0.05 versus WT animals. Scale bar = 100 μm.