Figure 6.

Sequence alignments of 5′ and 3′ NCR sequences of Nairovirus S-segment vRNA. Thirty nucleotides from both 5′ and 3′ termini of S-segment vRNA of 10 Nairoviruses were aligned. It is evident that the terminal nucleotides are highly conserved. The 30 nucleotides from both 5′ and 3′ termini of S-segment vRNA, separated by a six-residue uracil loop, of hazara virus and CCHFV were folded by MFold. The folded panhandle structures are shown. The S-segment vRNA panhandle of Andes hantavirus is also shown.