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Proposed model of PKCα-dependent Twist1 stabilization. A, Twist1 is a target for ubiquitination around the loop region. Twist1 3D structure is shown in green dimerized with another bHLH protein shown in gray. B, active PKCα binds to Twist1 via Twist1's WR domain and phosphorylates Twist1 on Ser-144 located in the loop region. This phosphorylation precludes ubiquitination, leading to Twist1 stabilization.
