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Deletion of Munc18-2 in platelets disrupts hemostasis and thrombosis. A and B, tail bleeding times that depends mostly on arterial (A) and venous (B) bleeding were recorded in Munc18-2 mutant mice. n = 8–10. C, time to carotid occlusion after applying FeCl3 abluminally for 3 min. n = 6–8. Circle, individual mouse; horizontal line, mean. #, p < 0.05; †, p ≤ 0.01; *, p ≤ 0.001; comparisons are to WT controls (+/+) unless otherwise specified.
