Table 2.
Off-hemodialysis ranolazine pharmacokinetic parameters for patients receiving 500 mg or 1000 mg of oral ranolazine doses.
| Parameter Mean ± SD |
Received 500 mg of ranolazine (N = 3) |
Received 1000 mg of ranolazine (N = 4)a |
|---|---|---|
| Maximum concentration (mcg/mL) | 0.65 ± 0.27 | 1.18 ± 0.48 |
| Time to maximum concentration (hr) | 8 ± 4 | 4.5 ± 2.5 |
| Elimination phase apparent half-life (hr) | 3.6 ± 1.73 | 3.9 ± 0.55 |
| Area under the curve 0–18 hr (hr* mcg/mL) | 6.17 ± 3.2 | 10.33 ± 4.87 |
| Apparent volume of distribution (L/kg) | 14.37 ± 3.2b | 7.3 ± 1.5 |
| Apparent off-hemodialysis clearance (L/hr/kg) | 0.66 ± 0.23b | 1.34 ± 0.41 |
a
Excludes the data from 1 participant who had inconsistent plasma ranolazine results.
b
Excludes the data from 1 participant who had ranolazine concentrations below the LLOQ after 15 h.