Table 3.

Inflammatory cytokine panel and liver function of subjects at baseline to 22 h.

	Baseline		Hour 2		Hour 12		Hour 22
	treatment	Placebo	treatment	Placebo	treatment	Placebo	treatment	Placebo
CRP	0.89 ± 0.97	0.72 ± 0.88	0.90 ± 0.92	0.72 ± 0.82	0.83 ± 0.72	0.68 ± 0.79	0.86 ± 0.87	0.73 ± 0.85
Inflammatory cytokine panel
TNF-α	4.74 ± 1.10	5.07 ± 1.39	4.74 ± 1.03	5.00 ± 1.25	4.25 ± 1.14	4.52 ± 0.74	5.16 ± 1.68	5.30 ± 1.16
IL-1β	8.27 ± 3.73	7.81 ± 1.88	7.32 ± 1.79	7.82 ± 1.84	7.48 ± 1.79	7.60 ± 2.09	8.47 ± 1.92	8.40 ± 2.73
IL-2	4.17 ± 0.65	4.48 ± 0.83	4.15 ± 0.51	4.23 ± 0.84	4.01 ± 0.65	3.96 ± 0.64	4.43 ± 0.91	4.71 ± 1.14
IL-4	5.39 ± 1.60	5.09 ± 1.10	5.08 ± 1.56	5.27 ± 1.44	4.76 ± 1.57	4.79 + 0.63	5.92 ± 2.26	5.21 ± 1.07
IL-5	4.36 ± 1.55	4.16 ± 0.98	405 ± 1.07	4.67 ± 1.05	3.90 ± 1.00	4.45 ± 1.79	4.15 ± 0.94	4.70 ± 1.75
IL-6	2.94 ± 0.26	3.02 ± 0.05	3.02 ± 0.05	3.02 ± 0.05	3.00 ± 0.38	2.97 ± 0.13	3.27 ± 0.46	3.06 ± 0.14
IL-8	4.83 ± 0.79	5.24 ± 1.07	4.68 ± 0.73	4.77 ± 0.78	8.72 ± 4.84	5.69 ± 1.40	5.28 ± 0.68	4.19 ± 0.81#
IL-10	3.82 ± 0.61	4.35 ± 0.76	4.15 ± 0.62	4.04 ± 0.56	3.92 ± 0.40	4.10 ± 0.71	4.09 ± 0.45	4.23 ± 0.71#
IL-12p70	3.98 ± 0.80	4.99 ± 1.49	4.30 ± 0.70	4.48 ± 0.65	4.02 ± 0.54	4.41 ± 0.96	4.54 ± 0.84	4.62 ± 0.64#
IL-13	4.88 ± 0.94	4.84 ± 0.88	4.90 ± 0.96	5.21 ± 1.03	4.70 ± 0.74	4.61 ± 0.82	4.84 ± 0.84	5.11 ± 0.99
IL-17A	3.61 ± 0.47	3.87 ± 0.74	3.63 ± 0.48	3.73 ± 0.46	4.00 ± 0.53	3.68 ± 0.45	3.53 ± 0.52	3.67 ± 0.49
GM-CSF factor	5.87 ± 0.99	5.84 ± 0.53	5.55 ± 0.48	6.24 ± 0.78	5.51 ± 0.63	5.85 ± 0.80	6.27 ± 1.16	6.23 ± 1.01
Eotaxin	54.10 ± 39.89	68.67 ± 44.12	61.07 ± 50.93	55.02 ± 30.01	90.33 ± 61.2	92.93 ± 62.66	98.57 ± 67.84	87 ± 61.56
MIP-1beta	422.67 ± 161.14	410.72 ± 171.99	411.07 ± 195.48	381.52 ± 176.67	556.52 ± 183.08	586.23 ± 222.62	462.71 ± 145.04	485.18 ± 197.25
IFN-γ	5.67 ± 1.77	6.40 ± 2.10	5.66 ± 1.63	5.49 ± 1.26	5.54 ± 2.04	6.03 ± 2.62	5.78 ± 1.91	6.18 ± 2.32
VEGF	47.86 ± 24.02	61.67 ± 40.74	45.65 ± 24.23	51.33 ± 30.81	57.64 ± 37.68	64.72 ± 44.88	54.89 ± 29.34	62.12 ± 37.67
MCP-1	16.43 ± 6.31	15.54 ± 4.66	14.35 ± 5.09	15.15 ± 4.66	18.28 ± 5.21	20.64 ± 8.28	16.8 ± 4.67	17.55 ± 5.80
FGF-basic	4.31 ± 0.46	4.46 ± 0.51	4.30 ± 0.59	4.50 ± 0.56	4.55 ± 0.89	4.32 ± 0.46	4.70 ± 0.45	4.51 ± 0.50
Liver function tests
AST	21.8 ± 8.61	18.13 ± 5.30	21.6 ± 8.26	18.87 ± 5.14	18.79 ± 6.58	17.07 ± 3.9	17.08 ± 4.91	17.27 ± 3.84
ALT	18.13 ± 8.79	16 ± 5.68	18.33 ± 8.74	16.13 ± 5.65	16.21 ± 8.38	15.4 ± 5.15	15.92 ± 8.25	15.53 ± 5.64
Total bilirubin	0.51 ± 0.2	0.49 ± 0.22	0.48 ± 0.15	0.47 ± 0.17	0.42 ± 0.15	0.39 ± 0.12	0.59 ± 0.21	0.54 ± 0.22
Albumin	4.53 ± 0.29	4.41 ± 0.32	4.59 ± 0.35	4.45 ± 0.34	4.36 ± 0.35	4.36 ± 0.43	4.41 ± 0.31	4.45 ± 0.41
INR	1.04 ± 0.07	1.03 ± 006	1.03 ± 0.07	1.04 ± 0.06	1.06 ± 0.11	1.07 ± 0.09	1.06 ± 0.08	62.47 ± 14.88
ALK	63.88 ± 13.08	67.44 ± 14.17	66.31 ± 14.62	69.84 ± 13.31	62.84 ± 14.76	67.41 ± 15.23	62.47 ± 14.88	67.88 ± 15.61
GSH-Px	69.89 ± 15.77	74.69 ± 16.18	70.46 ± 15.52	71.48 ± 14.27	70.79 ± 9.60	75.3 ± 13.26	73.79 ± 11.66	76.86 ± 12.88

^# p < 0.05, Denotes significant difference of active compared to placebo.