Table 7.
Top Medications for Symptoms
| Symptoms | Medication (benefit rating) |
|---|---|
| Aggression/agitation | Oxcarbazepine (0.33), Lamotrigine (0.28), Guanfacine (0.21), Aripiprazole (0.16), Clonidine (0.16), Sertraline (0.14), Fluoxetine (0.13), Buspirone (0.12) |
| Anxiety | Sertraline (0.55), Buspirone (0.38), Citalopram (0.33), Fluoxetine (0.32), Diazepam (0.29), Oxcarbazepine (0.26), Clonidine (0.21), Escitalopram (0.19), Guanfacine (0.18), Lamotrigine (0.14) |
| Attention | Guanfacine (0.42), Amphetamine (0.20), Dexmethylphenidate (0.16), Clonidine (0.11) |
| Cognition (ability to think) | Guanfacine (0.21), Dexmethylphenidate (0.09), Sertraline (0.07) |
| Depression | Sertraline (0.23), Citalopram (0.21), Escitalopram (0.18), Fluoxetine (0.16) |
| General benefit, no one particular symptom | Clonidine (0.09), Lamotrigine (0.07), Escitalopram (0.07) |
| Hyperactivity | Guanfacine (0.27), Clonidine (0.20), Amphetamine (0.18), Oxcarbazepine (0.11), Dexmethylphenidate (0.10), Sertraline (0.10) |
| Irritability | Oxcarbazepine (0.18), Lamotrigine (0.14), Sertraline (0.14), Guanfacine (0.12), Clonidine (0.12), Fluoxetine (0.10), Buspirone (0.10) |
| Language/communication | Sertraline (0.04), Guanfacine (0.03), Divalproex Sodium (0.02) |
| Lethargy (easily tired) | Diazepam (0.06), Clonidine (0.02), Buspirone (0.02) |
| OCD | Sertraline (0.12), Fluoxetine (0.08), Citalopram (0.08) |
| Seizures | Lamotrigine (0.38), Levetiracetam (0.33), Oxcarbazepine (0.29), Diazepam (0.12) |
| Self-injury | Lamotrigine (0.07), Buspirone (0.04), Citalopram (0.04) |
| Sensory sensitivity | Oxcarbazepine (0.11), Guanfacine (0.07), Amphetamine (0.05) |
| Sleep (falling asleep) | Clonidine (0.59), Guanfacine (0.11), Clonazepam (0.06) |
| Sleep (staying asleep) | Clonidine (0.39), Guanfacine (0.08), Lamotrigine (0.07) |
| Social interaction and understanding | Guanfacine (0.10), Sertraline (0.10), Amphetamine (0.05) |
| Stimming/perseveration/desire for sameness | Escitalopram (0.04), Oxcarbazepine (0.04), Diazepam (0.03) |
| Tics/abnormal movements | Guanfacine (0.10), Amphetamine (0.02), Clonazepam (0.02) |
The benefit rating is calculated based on the net benefit (overall benefit minus overall adverse) × % of participants reporting that symptom as a primary benefit. So, higher scores suggest more benefit for that symptom. For each symptom, we report the top three rated medications, and continue rating until the score drops <0.1.
OCD, obsessive-compulsive disorder.