Figure 8.

Epigenetic editing enzymes are dispensable in mature podocytes. (A) Representative PAS-stained mouse kidney sections of control (Dnmt1^f/f) and mice with podocyte-specific deletion of Dnmt1, Dnmt3a, Dnmt3b, Dnmt3a/3b, and Tet. (B) Albuminuria (urine albumin-to-creatinine, micrograms per milligram) of Dnmt1^f/f and Pod^Cre Dnmt1^f/f mice at baseline and 20 weeks after streptozotocin-induced diabetes. (C–E) Albuminuria (urine albumin-to-creatinine, micrograms per milligram) of control, Pod^Cre Dnmt1^f/f, Pod^Cre Dnmt3b^f/f, and Pod^Cre Tet2^f/f mice at baseline and 7 days after doxorubicin-induced glomerular injury.