Table 1.
Baseline characteristics for patients entering the RTP and RWP
| Characteristic | RTP | RWP | |||
|---|---|---|---|---|---|
| Tenapanor | Placebo, n=82 | Pooled Tenapanor, n=82 | |||
| 3 mg Twice Daily, n=74 | 10 mg Twice Daily, n=73 | 30 mg Twice Daily Titration, n=71 | |||
| Age, yr | 55.7±11.5 | 57.4±10.8 | 54.2±10.9 | 55.8±11.8 | 55.2±10.4 |
| Men, n (%) | 46 (62.2) | 34 (46.6) | 48 (67.6) | 44 (53.7) | 52 (63.4) |
| Race, n (%) | |||||
| White | 30 (40.5) | 25 (34.2) | 30 (42.3) | 26 (31.7) | 29 (35.4) |
| Black | 40 (54.1) | 45 (61.6) | 40 (56.3) | 51 (62.2) | 51 (62.2) |
| Asian | 2 (2.7) | 0 (0.0) | 0 (0.0) | 2 (2.4) | 0 (0.0) |
| Native American or Alaskan native | 1 (1.4) | 2 (2.7) | 1 (1.4) | 2 (2.4) | 2 (2.4) |
| Other | 1 (1.4) | 1 (1.4) | 0 (0.0) | 1 (1.2) | 0 (0.0) |
| Ethnicity, n (%) | |||||
| Hispanic or Latino | 13 (17.6) | 8 (11.0) | 18 (25.4) | 12 (14.6) | 16 (19.5) |
| Baseline BMI, kg/m2 | 32.5±8.5 | 33.6±8.5 | 33.4±8.1 | 33.0±7.9 | 34.3±8.2 |
| Duration since first hemodialysis, mo | 58.1±63.1 | 62.0±53.1 | 57.1±57.1 | 55.7±52.2 | 57.9±51.7 |
| Kt/V valuea | NA | 1.62±0.38 | 1.61±0.28 | 1.63±0.32 | 1.61±0.34 |
| Serum phosphate, mg/dlb | 7.40±1.57 | 7.46±1.69 | 7.62±1.43 | NA | NA |
| PTH value before study entry, pg/ml | 471±268 | 393±237 | 433±213 | 405±206 | 443±241 |
Data are mean±SD unless otherwise stated. BMI, body mass index; Kt/V, a marker of dialysis adequacy, where K is dialyzer clearance of urea, t is dialysis time, and V is volume distribution of urea (approximately equal to the participant’s total body water); NA, not applicable/available; PTH, parathyroid hormone.
a
Data for 3 mg twice a day group not included due to a recording error.
b
On day 1, i.e., postwashout of phosphate binders.